Biogenic Amines: Toxicology and Health Effect

BAs play essential roles in the normal development, metabolism, and physiological functions of humans. However, they are very frequently involved in human pathologies causing neurological disorders, gastrointestinal diseases, abnormal immune responses, cancer, etc. Further studies are needed to evaluate the factors influencing BAs formation to understand how these compounds could affect consumers. In addition, there are large gaps in the establishment of dose–effect relationship. The role of various substances that enhance the toxicity of BAs and the existence of synergic effects has been demonstrated, and therefore, the determination of the amine concentrations in each case is not enough to assess their toxicpotential.