A highly stereoselective enantiodivergent synthesis of non-racemic 3,3,3- trifluoroalanine 7 is reported. The methodology is based on the reduction, by 9-BBN or DIBAH, of the chiral sulfinimine 3 derived from ethyl trifluoropyruvate, followed by acidic hydrolysis of the resulting diastereomeric sulfinamides 4 and 5.
Titolo: | Facile and stereoselective synthesis of non-racemic 3,3,3-trifluoroalanine |
Autori: | |
Data di pubblicazione: | 2000 |
Rivista: | |
Abstract: | A highly stereoselective enantiodivergent synthesis of non-racemic 3,3,3- trifluoroalanine 7 is reported. The methodology is based on the reduction, by 9-BBN or DIBAH, of the chiral sulfinimine 3 derived from ethyl trifluoropyruvate, followed by acidic hydrolysis of the resulting diastereomeric sulfinamides 4 and 5. |
Handle: | http://hdl.handle.net/11575/9967 |
Appare nelle tipologie: | 1.1 Articolo in rivista |
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