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Oropouche Virus: An Overview of the Current Status of Diagnostics

The Orthobunyavirus Oropouche (OROV) has become an urgent public health threat in Central and South America, as well as in other countries worldwide. Since its initial identification, there have been over 30 outbreaks, with the largest reported in late 2024 in Brazil. This outbreak prompted an epidemiological alert due to a significant increase in OF cases in non-Amazonian states in the Americas region, as well as in European countries, where 44 imported cases were identified. Humans become i...

Barriers and enablers for traceability and federation in model-based digital twin engineering

Impaired NF-κB/Nrf2 Crosstalk in Rett Syndrome

Stress induced hyperphagia in C. elegans as a genetic model for binge eating disorders

Binge eating (BE) is often triggered by stress, dieting, and adverse environmental factors, and represents a common precursor to eating disorders such as anorexia, bulimia, and BE disorder. Stress-induced hyperphagia captures core features of binge-like feeding and shares neurobiological substrates will BE disorder, making it a useful behavioral readout for dissecting underlying mechanisms. We used the genetically tractable worm Caenorhabditis elegans to examine how starvation and stress inte...

In vitro cultivation of Trypanosoma equiperdum: Comparison of in vitro and in vivo antigens for an ethical and sustainable serological diagnosis of Dourine

The protozoan Trypanosoma equiperdum is the causative agent of Dourine, a contagious sexually transmitted disease of equines that can manifest itself in chronic or acute form. Dourine has serious veterinary and economic implications, as there are no vaccines available for prevention and the management of the disease requires the culling of infected animals, together with rigorous sanitary control measures. This study compares the traditional production of T. equiperdum antigen grown in vivo, ...

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