The present Letter comments the fascinating article by Dr Gunn-Moore and coworkers, reporting for the first time Alzheimer’s disease (AD)-related pathological findings in the brain tissue from two wild dolphin species. In this respect, based upon the crucial role played by the cellular prion protein (PrPC) in AD pathogenesis, characterizing the expression levels of PrPC within different brain areas from the aforementioned cetaceans would probably allow to gain valuable pathogenetic insights into their AD-like neuropathy, thereby contributing to qualify dolphins as “reliable comparative neuropathology models” for AD in humans.
Alzheimer’s disease, cellular prion protein, and dolphins
Di Guardo, Giovanni
Writing – Original Draft Preparation
2018-01-01
Abstract
The present Letter comments the fascinating article by Dr Gunn-Moore and coworkers, reporting for the first time Alzheimer’s disease (AD)-related pathological findings in the brain tissue from two wild dolphin species. In this respect, based upon the crucial role played by the cellular prion protein (PrPC) in AD pathogenesis, characterizing the expression levels of PrPC within different brain areas from the aforementioned cetaceans would probably allow to gain valuable pathogenetic insights into their AD-like neuropathy, thereby contributing to qualify dolphins as “reliable comparative neuropathology models” for AD in humans.File in questo prodotto:
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