Canine prostatic carcinoma (PCa) is considered a relevant model for studying human advanced PCa. Survivin is proposed as a cancer biomarker for malignancy in human prostatic cancer. Sox9 is a stem cell marker expressed in several adult tissues, required for prostate development. The aims of the present study were to evaluate the patterns and levels of expression of survivin and Sox9 in canine benign prostatic hyperplasia (BPH) and PCa, and the potential colocalization with androgen receptor (AR) and p63.

Contribution of Stem Cells to Benign and Malignant Canine Prostate Tissues

BONGIOVANNI, LAURA;CICCARELLI, Andrea;ROMANUCCI, MARIARITA;MALATESTA, DANIELA;MASSIMINI, MARCELLA;DELLA SALDA, Leonardo
2015

Abstract

Canine prostatic carcinoma (PCa) is considered a relevant model for studying human advanced PCa. Survivin is proposed as a cancer biomarker for malignancy in human prostatic cancer. Sox9 is a stem cell marker expressed in several adult tissues, required for prostate development. The aims of the present study were to evaluate the patterns and levels of expression of survivin and Sox9 in canine benign prostatic hyperplasia (BPH) and PCa, and the potential colocalization with androgen receptor (AR) and p63.
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11575/96878
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