Mitochondrial DNA (mtDNA) plays a key role in the development of a competent oocyte. In this study, the complete mtDNA sequence obtained for the first time by multiple displacement amplification approach in combination with next-generation sequencing from a single human oocyte is reported (GenBank accession no. KT364276). The analysis of oocyte mitochondria' mutations could provide a better understanding of the genetic variants correlated with the oocyte quality.
|Titolo:||Complete sequence of human mitochondrial DNA obtained by combining multiple displacement amplification and next-generation sequencing on a single oocyte|
|Autori interni:||COLOSIMO, Alessia|
|Data di pubblicazione:||2017|
|Rivista:||MITOCHONDRIAL DNA. PART A. DNA MAPPING, SEQUENCING, AND ANALYSIS|
|Appare nelle tipologie:||1.1 Articolo in rivista|