Mitochondrial DNA (mtDNA) plays a key role in the development of a competent oocyte. In this study, the complete mtDNA sequence obtained for the first time by multiple displacement amplification approach in combination with next-generation sequencing from a single human oocyte is reported (GenBank accession no. KT364276). The analysis of oocyte mitochondria' mutations could provide a better understanding of the genetic variants correlated with the oocyte quality.
Complete sequence of human mitochondrial DNA obtained by combining multiple displacement amplification and next-generation sequencing on a single oocyte
COLOSIMO, Alessia;RUSSO, Valentina;BARBONI, Barbara;
2017-01-01
Abstract
Mitochondrial DNA (mtDNA) plays a key role in the development of a competent oocyte. In this study, the complete mtDNA sequence obtained for the first time by multiple displacement amplification approach in combination with next-generation sequencing from a single human oocyte is reported (GenBank accession no. KT364276). The analysis of oocyte mitochondria' mutations could provide a better understanding of the genetic variants correlated with the oocyte quality.File in questo prodotto:
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