The palladium-catalyzed arylation of the α-methylene-γ-butyrolactone proceeds in good yields and may be directed toward the synthesis of 3-benzylfuran-2(5H)-ones when the starting aryl iodides contain strongly electron-withdrawing groups. The combined palladium-catalyzed arylation/hydrogenation of the α-methylene-γ-butyrolactone represents a new simple entry into functionalized α-benzyl-γ-butyrolactones.
Palladium-Catalyzed Arylation of alfa-Methylene-gamma-butyrolactone: 3-Benzylfuran-2(5H)-ones vs (Z)-Benzylidene-gamma-butyrolactones and Their Reduction to 3-Benzyl-gamma-butyrolactones
CHIARINI, MARCO;
2000-01-01
Abstract
The palladium-catalyzed arylation of the α-methylene-γ-butyrolactone proceeds in good yields and may be directed toward the synthesis of 3-benzylfuran-2(5H)-ones when the starting aryl iodides contain strongly electron-withdrawing groups. The combined palladium-catalyzed arylation/hydrogenation of the α-methylene-γ-butyrolactone represents a new simple entry into functionalized α-benzyl-γ-butyrolactones.File in questo prodotto:
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