Introduction: Canine rhabdomyosarcomas (RBDs) are classifiedinto embryonal, botryoid, alveolar and pleomorphic forms. Althoughrare, the embryonal type is the most common and is reported to havea locally invasive behaviour and metastatic potential.Materials and Methods: An 11-year-old pointer had a subcutaneousmass in the left forearm and an enlarged prescapular lymph node.Cytology, immunocytochemistry (ICC), histology and electron microscopy(EM) were performed.Results: Cytology of the mass and lymph node showed neoplasticcells with morphological features consistent with an undifferentiatedsarcoma. Cytological atypia was severe. Histology revealed a subcutaneous,unencapsulated neoplasm composed of sheets of cells with thesame morphology observed in aspirates. The lymph node was positivefor metastasis. Expression of vimentin, desmin and myoglobin wasdemonstrated using ICC and indicated a diagnosis of RBD. EM revealednumerous mitochondria, large nuclei and nucleoli and raredense masses of tangled myofilaments, suggestive of poorly differentiatedrhabdomyoblasts. The findings were consistent with an embryonalRBD. Six months after treatment the dog remains free of disease.Conclusions: Cytology and ICC are pivotal for the diagnosis ofRBD. Despite the guarded prognosis, in this case of metastatic embryonalRBD the dog responded well to therapy.[...]

Subcutaneous embryonal rhabdomyosarcoma in a dog

PALMIERI, CHIARA;DELLA SALDA, Leonardo;
2009

Abstract

Introduction: Canine rhabdomyosarcomas (RBDs) are classifiedinto embryonal, botryoid, alveolar and pleomorphic forms. Althoughrare, the embryonal type is the most common and is reported to havea locally invasive behaviour and metastatic potential.Materials and Methods: An 11-year-old pointer had a subcutaneousmass in the left forearm and an enlarged prescapular lymph node.Cytology, immunocytochemistry (ICC), histology and electron microscopy(EM) were performed.Results: Cytology of the mass and lymph node showed neoplasticcells with morphological features consistent with an undifferentiatedsarcoma. Cytological atypia was severe. Histology revealed a subcutaneous,unencapsulated neoplasm composed of sheets of cells with thesame morphology observed in aspirates. The lymph node was positivefor metastasis. Expression of vimentin, desmin and myoglobin wasdemonstrated using ICC and indicated a diagnosis of RBD. EM revealednumerous mitochondria, large nuclei and nucleoli and raredense masses of tangled myofilaments, suggestive of poorly differentiatedrhabdomyoblasts. The findings were consistent with an embryonalRBD. Six months after treatment the dog remains free of disease.Conclusions: Cytology and ICC are pivotal for the diagnosis ofRBD. Despite the guarded prognosis, in this case of metastatic embryonalRBD the dog responded well to therapy.[...]
File in questo prodotto:
Non ci sono file associati a questo prodotto.

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11575/3825
Citazioni
  • ???jsp.display-item.citation.pmc??? ND
  • Scopus ND
  • ???jsp.display-item.citation.isi??? 0
social impact