Adolescent cannabis use produces lasting and sex-specific effects into adulthood, although poorly explained mechanistically. This study links these cannabis-induced effects to sex-dependent changes in phosphorylation of mitochondrial Complex I subunit NDUFS4 during adolescence, identifying mitochondrial pathways as causal mechanisms and potential therapeutic targets to reduce their long-term consequences.
A transient mitochondrial switch underlies long lasting effects of adolescent cannabis
Di Bartolomeo, Martina;
2026-01-01
Abstract
Adolescent cannabis use produces lasting and sex-specific effects into adulthood, although poorly explained mechanistically. This study links these cannabis-induced effects to sex-dependent changes in phosphorylation of mitochondrial Complex I subunit NDUFS4 during adolescence, identifying mitochondrial pathways as causal mechanisms and potential therapeutic targets to reduce their long-term consequences.File in questo prodotto:
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