Pressurized-liquid extraction for determination of illicit drugs in hair by LC–MS–MS

Sergi, M.; Napoletano, S.; Montesano, C.; Iofrida, R.; Curini, R.; Compagnone, D

doi:10.1007/s00216-012-6072-x

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An LC–MS–MS-based procedure for determination in hair of 14 different drugs of abuse belonging to the classes cocaine, amphetamine-like compounds, opiates, and hallucinogens has been developed. A pressurized-liquid extraction procedure was used and proved useful for quantitative recovery of all the analytes tested. This procedure, in conjunction with a simple decontamination step, performed to avoid false-positive samples, enabled the detection of all the analytes with LOQ ranging from 1.8 to 16 pg mg−1 and accuracy varying from 85 to 111 %. The procedure was validated in accordance with the SOFT/AAFS guidelines and seems to be suitable for routine determination of the drugs tested in hair.[...]

Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11575/16810

Titolo:	Pressurized-liquid extraction for determination of illicit drugs in hair by LC–MS–MS
Autori interni:	SERGI, Manuel COMPAGNONE, DARIO
Data di pubblicazione:	2013
Rivista:	ANALYTICAL AND BIOANALYTICAL CHEMISTRY
Abstract:	An LC–MS–MS-based procedure for determination in hair of 14 different drugs of abuse belonging to the classes cocaine, amphetamine-like compounds, opiates, and hallucinogens has been developed. A pressurized-liquid extraction procedure was used and proved useful for quantitative recovery of all the analytes tested. This procedure, in conjunction with a simple decontamination step, performed to avoid false-positive samples, enabled the detection of all the analytes with LOQ ranging from 1.8 to 16 pg mg−1 and accuracy varying from 85 to 111 %. The procedure was validated in accordance with the SOFT/AAFS guidelines and seems to be suitable for routine determination of the drugs tested in hair.[...]
Handle:	http://hdl.handle.net/11575/16810
Appare nelle tipologie:	1.1 Articolo in rivista

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