Follicular dendritic cells (FDCs) residing within ileal Peyer’s patches (PPs) are of crucial relevance for sheepscrapie early pathogenesis and subsequent scrapie prion neuroinvasion. In this study, ileal PP follicles were significantly more numerous in lambs than in adult Sarda breed sheep, with significant differences being also found in lymphoid follicle area, perimeter and FDC density. Furthermore, PrPd depositionwithin ileal PPs and host’s PrP genotype did not significantly influence these parameters. We conclude thatage significantly affects FDC density in ileal PPs from Sarda breed ovines, independently from host’s scrapie status and PrP genotype.[...]
Age, scrapie status, PrP genotype and follicular dendritic cells in ovine ileal Peyer's patches
MARRUCHELLA, GIUSEPPE;DI GUARDO, Giovanni
2012-01-01
Abstract
Follicular dendritic cells (FDCs) residing within ileal Peyer’s patches (PPs) are of crucial relevance for sheepscrapie early pathogenesis and subsequent scrapie prion neuroinvasion. In this study, ileal PP follicles were significantly more numerous in lambs than in adult Sarda breed sheep, with significant differences being also found in lymphoid follicle area, perimeter and FDC density. Furthermore, PrPd depositionwithin ileal PPs and host’s PrP genotype did not significantly influence these parameters. We conclude thatage significantly affects FDC density in ileal PPs from Sarda breed ovines, independently from host’s scrapie status and PrP genotype.[...]I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
