Cell stress and death are linked in the neoplastic process,and heat shock proteins appear to play an importantrole by inhibiting apoptotic pathways. The apoptoticrates in 9 canine infundibular keratinizing acanthomas(IKAs) and 17 canine squamous cell carcinomas(SCCs) were correlated with the immunohistochemicalexpression of caspase-3 and the antiapoptotic heatshock proteins Hsp27, 72 and 73. Apoptosis was evaluatedusing the terminal deoxynucleotidyl transferasebiotin-dUTP nick end labelling (TUNEL) method.The absence of a correlation between the TUNELindex and active-caspase-3 expression, a paucity ofactive-caspase-3-positive cells and Hsp72 overexpressionwere considered to be indicative ofinhibition of apoptosis, and suggestive that inhibitionof cell death plays a key role in oncogenesis andtumour growth of some canine skin neoplasms.[...]

Apoptosis and anti-apoptotic heat shock proteins in canine cutaneous infundibular keratinizing acanthomas and squamous cell carcinomas

BONGIOVANNI, LAURA;ROMANUCCI, MARIARITA;DELLA SALDA, Leonardo
2008

Abstract

Cell stress and death are linked in the neoplastic process,and heat shock proteins appear to play an importantrole by inhibiting apoptotic pathways. The apoptoticrates in 9 canine infundibular keratinizing acanthomas(IKAs) and 17 canine squamous cell carcinomas(SCCs) were correlated with the immunohistochemicalexpression of caspase-3 and the antiapoptotic heatshock proteins Hsp27, 72 and 73. Apoptosis was evaluatedusing the terminal deoxynucleotidyl transferasebiotin-dUTP nick end labelling (TUNEL) method.The absence of a correlation between the TUNELindex and active-caspase-3 expression, a paucity ofactive-caspase-3-positive cells and Hsp72 overexpressionwere considered to be indicative ofinhibition of apoptosis, and suggestive that inhibitionof cell death plays a key role in oncogenesis andtumour growth of some canine skin neoplasms.[...]
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11575/13802
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