Background: Alopecia X in Pomeranians is caused by a hair cycle deregulation, associated with downregulation of key regulatory genes of the Wnt and Shh pathways, and stem-cell markers. However, the pathogenesis remains unclear. p63 is an important transcription factor correlated with the aforementioned hair cycle modulating genes. Hypothesis/objectives: The aim of this study was to highlight possible changes of p63 immunohistochemical expression within the hair follicles in canine alopecia X compared with normal skin. Animals: Skin biopsies from 19 alopecia X-affected and six control Pomeranians were analysed. Materials and methods: Serial histological sections of skin biopsies harbouring anagen, telogen and kenogen hair follicles were immunohistochemically evaluated for differences in p63 expression in the affected and control samples. Results: Dogs with alopecia X had a significantly decreased immunoexpression of p63 in telogen and kenogen hair follicles. Conclusions and clinical relevance: The decrease of p63 immunoexpression observed in canine alopecia X suggests an involvement of p63 in hair cycle.

p63 immunoexpression in hair follicles of normal and alopecia X-affected skin of Pomeranian dogs

Della Salda, Leonardo
;
Bongiovanni, Laura;Massimini, Marcella;Romanucci, Mariarita;Colosimo, Alessia;Di Matteo, Ramona;Defourny, Sabrina Vanessa Patrizia
2023-01-01

Abstract

Background: Alopecia X in Pomeranians is caused by a hair cycle deregulation, associated with downregulation of key regulatory genes of the Wnt and Shh pathways, and stem-cell markers. However, the pathogenesis remains unclear. p63 is an important transcription factor correlated with the aforementioned hair cycle modulating genes. Hypothesis/objectives: The aim of this study was to highlight possible changes of p63 immunohistochemical expression within the hair follicles in canine alopecia X compared with normal skin. Animals: Skin biopsies from 19 alopecia X-affected and six control Pomeranians were analysed. Materials and methods: Serial histological sections of skin biopsies harbouring anagen, telogen and kenogen hair follicles were immunohistochemically evaluated for differences in p63 expression in the affected and control samples. Results: Dogs with alopecia X had a significantly decreased immunoexpression of p63 in telogen and kenogen hair follicles. Conclusions and clinical relevance: The decrease of p63 immunoexpression observed in canine alopecia X suggests an involvement of p63 in hair cycle.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11575/135120
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