The retinal pigment epithelium (RPE) is a specialized epithelium that forms the outer blood–retinal barrier (BRB), located between the retinal photoreceptors and the choriocapillaris. The tight junctions expressed in this epithelium control fluids and solutes that enter the retina and participates to the maintenance of photoreceptors homeostasis.This epithelium is damaged in many retinal diseases, but in particular by the high glucose levels in blood in patients with diabetes mellitus. Diabetic retinopathy is a diabetes complication and the leading cause of blindness in the industrialized world. The aim of this study was to characterize a diabetic retinopathy in vitro model using high glucose-injured RPE cell line (ARPE-19) that can help understand the biological processes underlying retinal diseases.
DEVELOPMENT AND CHARACTERIZATION OF A DIABETIC RETINOPATHY IN VITRO MODEL
Barbara Barboni;
2021-01-01
Abstract
The retinal pigment epithelium (RPE) is a specialized epithelium that forms the outer blood–retinal barrier (BRB), located between the retinal photoreceptors and the choriocapillaris. The tight junctions expressed in this epithelium control fluids and solutes that enter the retina and participates to the maintenance of photoreceptors homeostasis.This epithelium is damaged in many retinal diseases, but in particular by the high glucose levels in blood in patients with diabetes mellitus. Diabetic retinopathy is a diabetes complication and the leading cause of blindness in the industrialized world. The aim of this study was to characterize a diabetic retinopathy in vitro model using high glucose-injured RPE cell line (ARPE-19) that can help understand the biological processes underlying retinal diseases.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
