Introduction Novel scaffold approach is a potential alternative for tendon regeneration. Natural healing capacity of tendons is limited. Several conventional approaches are available for tendon repair but all have their own limitations. Regenerative medicine and tissue engineering aspire to develop functional substitutes by combining embryonic cells, degradable polymers and immune modulators for tendon tissue repair. Materials & Methods Nanoparticles will be prepared and characterizationed (Paolino et al., 2013). Bioscaffold will be synthesized and characterized co-loaded with nanoparticles and growth factors (He et al., 2005). Then Implanted in ovine preclinical rabbit model (Chen., et al, 2009) for veterinary clinical trials. Future perspectives and discussion Bioscaffolds exhibit several unique properties, such as biocompatibility, porosity and mechanical strength. We would like to synthesize and test biocompatible scaffolds integrated with nanoparticles for co-delivery of bioactive compounds for tendon tissue regeneration and then tested in ovine preclinical rabbit model. Conclusion Countless efforts have been made, treatment of tendon injuries still remains a challenge. An efficient strategy is the need of hour for tendon tissue engineering. We are working to synthesize biocompatible scaffolds integrated with nanoparticles and growth facors.
Development of bio-scaffolds for tendon regeneration
Hafeez;
2019-01-01
Abstract
Introduction Novel scaffold approach is a potential alternative for tendon regeneration. Natural healing capacity of tendons is limited. Several conventional approaches are available for tendon repair but all have their own limitations. Regenerative medicine and tissue engineering aspire to develop functional substitutes by combining embryonic cells, degradable polymers and immune modulators for tendon tissue repair. Materials & Methods Nanoparticles will be prepared and characterizationed (Paolino et al., 2013). Bioscaffold will be synthesized and characterized co-loaded with nanoparticles and growth factors (He et al., 2005). Then Implanted in ovine preclinical rabbit model (Chen., et al, 2009) for veterinary clinical trials. Future perspectives and discussion Bioscaffolds exhibit several unique properties, such as biocompatibility, porosity and mechanical strength. We would like to synthesize and test biocompatible scaffolds integrated with nanoparticles for co-delivery of bioactive compounds for tendon tissue regeneration and then tested in ovine preclinical rabbit model. Conclusion Countless efforts have been made, treatment of tendon injuries still remains a challenge. An efficient strategy is the need of hour for tendon tissue engineering. We are working to synthesize biocompatible scaffolds integrated with nanoparticles and growth facors.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
