Introduction / Purpose: 2-D shear wave elastography is a widely applied tool to asses tissue mechanical properties in healthy and diseased organs. This study aimed to investigate the possibility to assess the progressive lens age-related stiffness compared to lenses affected by cataract in dogs. Methods: Dogs were divided in four groups (group 1 <1.5 years, group 2 range 1.5-7 years, group 3 >7 years and group 4 dogs with cataract respectively) after a complete clinical and ophtalmological examination with owner consent. Trans-corneal B-mode US and elastography were performed under physical restraint with a Logiq S8 (GE Healthcare) and a linear probe (9L/10 MHz) with a 2-D shear wave elastography software. Triplicate kPa and m/s measurements were collected, and statistical analysis was performed with MATLAB 2020a. Results: 44 dogs were included (mean age group 1 0.37±0.07 years, group 2 4±1.8 years, group 3 11.3±1.3 years and group 4 9.7±5.1 years). Mean stiffness expressed in m/s and kPa was respectively 3.1±0.5 and 28.9±9.2 for group 1, 4.6±0.6 and 65±18.4 for group 2, 6.46±0.36 and 126±14.6 for group 3, 5.83±0.7 and 103±24 for group 4. Significant differences (P<0.05) were evidenced between all the 4 groups for both m/s and kPa measurements. Discussion / Conclusion: These preliminary results evidence that 2-D shear wave elastography is a feasible tool to assess agerelated stiffness change in aging dogs and in case of cataract; wider groups of dogs affected by different types of cataract are needed to assess different grades of stiffness related to the underlying cataract etiology.

EVALUATION OF SHEAR WAVE ELASTOGRAPHY TO ASSESS CANINE LENS STIFFNESS IN AGING SUBJECTS AND IN CASE OF CATARACT

F. del Signore
;
G. Amatori;G. Aste;M. C. Pincelli;I. Falerno;R. Tamburro;M. Vignoli
2020

Abstract

Introduction / Purpose: 2-D shear wave elastography is a widely applied tool to asses tissue mechanical properties in healthy and diseased organs. This study aimed to investigate the possibility to assess the progressive lens age-related stiffness compared to lenses affected by cataract in dogs. Methods: Dogs were divided in four groups (group 1 <1.5 years, group 2 range 1.5-7 years, group 3 >7 years and group 4 dogs with cataract respectively) after a complete clinical and ophtalmological examination with owner consent. Trans-corneal B-mode US and elastography were performed under physical restraint with a Logiq S8 (GE Healthcare) and a linear probe (9L/10 MHz) with a 2-D shear wave elastography software. Triplicate kPa and m/s measurements were collected, and statistical analysis was performed with MATLAB 2020a. Results: 44 dogs were included (mean age group 1 0.37±0.07 years, group 2 4±1.8 years, group 3 11.3±1.3 years and group 4 9.7±5.1 years). Mean stiffness expressed in m/s and kPa was respectively 3.1±0.5 and 28.9±9.2 for group 1, 4.6±0.6 and 65±18.4 for group 2, 6.46±0.36 and 126±14.6 for group 3, 5.83±0.7 and 103±24 for group 4. Significant differences (P<0.05) were evidenced between all the 4 groups for both m/s and kPa measurements. Discussion / Conclusion: These preliminary results evidence that 2-D shear wave elastography is a feasible tool to assess agerelated stiffness change in aging dogs and in case of cataract; wider groups of dogs affected by different types of cataract are needed to assess different grades of stiffness related to the underlying cataract etiology.
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11575/110059
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