A powerful analytical method was developed for the simultaneous determination of traces of 63 pharmaceuticals and their metabolites representing different therapeutic classes: antibiotics, stimulant, antidepressant, mucolytic, antiparasite and dyes using SPE-LC-ESI-MS/MS in water samples. 100 samples from rivers, lakes, fountain and artesian wells were collected for this study overall Lebanon. Monitoring programs show the presence of many antibiotics in several analyzed samples. Therefore, to evaluate if a relation may exist between finding antibiotics in water samples and resistant-bacterial strains; three bacteria (Escherichia coli, Enterococcus faecalis and Pseudomonas aeruginosa) were selected for isolation, then antimicrobial susceptibility was determined using disk diffusion method according to the recommendations of the European Committee on Antimicrobial Susceptibility Testing.
OCCURRENCE OF 63 SELECTED PHARMACEUTICALS AND ISOLATION OF RESISTANT- BACTERIA STRAINS IN NATURAL WATER SOURCES IN LEBANON
EL KHATIB Mohammad;
2016-01-01
Abstract
A powerful analytical method was developed for the simultaneous determination of traces of 63 pharmaceuticals and their metabolites representing different therapeutic classes: antibiotics, stimulant, antidepressant, mucolytic, antiparasite and dyes using SPE-LC-ESI-MS/MS in water samples. 100 samples from rivers, lakes, fountain and artesian wells were collected for this study overall Lebanon. Monitoring programs show the presence of many antibiotics in several analyzed samples. Therefore, to evaluate if a relation may exist between finding antibiotics in water samples and resistant-bacterial strains; three bacteria (Escherichia coli, Enterococcus faecalis and Pseudomonas aeruginosa) were selected for isolation, then antimicrobial susceptibility was determined using disk diffusion method according to the recommendations of the European Committee on Antimicrobial Susceptibility Testing.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
