A practical metal-free approach to the synthesis of 2-aroyl-N-tosyl-1H-indole-3 carboxamides through an unprecedented sequential 5-endo-dig cycloamination /carboxamidation reaction of β-(2-aminophenyl)-α,β-ynones with the tosyl isocyanate is described. A computational model gives a plausible rationale for the unexpected results.

Reaction of β-(2-aminophenyl)-α,β-Ynones with Tosyl Isocyanate: Experimental and Computational Investigations

Marco Chiarini;
2018-01-01

Abstract

A practical metal-free approach to the synthesis of 2-aroyl-N-tosyl-1H-indole-3 carboxamides through an unprecedented sequential 5-endo-dig cycloamination /carboxamidation reaction of β-(2-aminophenyl)-α,β-ynones with the tosyl isocyanate is described. A computational model gives a plausible rationale for the unexpected results.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11575/101905
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