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EnglishIn humans, cardiac rhabdomyoma – characterized by glycogen-filed muscle cells with an occasional spiderwebappearance – represents the most common primary cardiac neoplasm in children, while it has beenrarely reported in veterinary medicine, except in pigs . The etiology and pathogenesis are still unknown andit is thought to be a hamartoma of myocardiocytes or, less likely, Purkinje fiber cells. The present casereport provides a wide ultrastructural description of a grossly and histologically diagnosed cardiacrhabdomyoma observed in a 2-years-old female wild boar. Trasmission electron microscopy revealed asevere cytoplasmic vacuolization associated with myofibrillar degeneration and occasional faint A and Hbands. Vacuoles contained amorphous granular material, glycogen, filaments and remnants of myofibrils.Moreover, the aberrant formation of sarcomeres, with accumulation of disorganized myofibrils, especiallythick filaments, and irregular deposits of Z band-like material, strongly supporting a variable degree ofmyofibrillar differentiation, were noted. Other features were leptofibrils, Z band streaming and hypertrophy,nemaline rods-like thickening of Z band, thick filaments whorling. Mitochondria displayed woollydensities, rods, cristae disorganization, vacuolization, vesicular cristae. As a conclusion, the ultrastructuralexamination confirmed the congenital dysplasia and severe degeneration of cardiac tissue and themyocardiocytes as cell of origin, as revealed by intercalated disks and tubular structures similar to Tsystem.[...]
| Titolo: | Modificazioni ultrastrutturali dei miocardiociti in un caso di rabdomioma cardiaco in un cinghiale (Sus scrofa) |
| Autori: | |
| Data di pubblicazione: | 2011 |
| Abstract: | In humans, cardiac rhabdomyoma – characterized by glycogen-filed muscle cells with an occasional spiderwebappearance – represents the most common primary cardiac neoplasm in children, while it has beenrarely reported in veterinary medicine, except in pigs . The etiology and pathogenesis are still unknown andit is thought to be a hamartoma of myocardiocytes or, less likely, Purkinje fiber cells. The present casereport provides a wide ultrastructural description of a grossly and histologically diagnosed cardiacrhabdomyoma observed in a 2-years-old female wild boar. Trasmission electron microscopy revealed asevere cytoplasmic vacuolization associated with myofibrillar degeneration and occasional faint A and Hbands. Vacuoles contained amorphous granular material, glycogen, filaments and remnants of myofibrils.Moreover, the aberrant formation of sarcomeres, with accumulation of disorganized myofibrils, especiallythick filaments, and irregular deposits of Z band-like material, strongly supporting a variable degree ofmyofibrillar differentiation, were noted. Other features were leptofibrils, Z band streaming and hypertrophy,nemaline rods-like thickening of Z band, thick filaments whorling. Mitochondria displayed woollydensities, rods, cristae disorganization, vacuolization, vesicular cristae. As a conclusion, the ultrastructuralexamination confirmed the congenital dysplasia and severe degeneration of cardiac tissue and themyocardiocytes as cell of origin, as revealed by intercalated disks and tubular structures similar to Tsystem.[...] |
| Handle: | http://hdl.handle.net/11575/9784 |
| Appare nelle tipologie: | 4.1 Contributo in Atti di convegno |
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