Superossido dismutasi e glutatione perossidasi in cani con Leishmaniosi dopo terapia antimoniale

The aim of this study was to evaluate the effect of antimony treatment on antioxidant enzyme activities of erythrocyte superoxide dismutase (SOD) and blood glutathione peroxidase (GSHPx) in dogs with canine visceral leishmaniasis (CanVL) and to detect the associations between these enzyme activities and haematological indices of anaemia (pre- and post-treatment). Twelve dogs with spontaneous CanVL were studied before and 60 days following subcutaneous N-methylglucamine administration. No significant differences in antioxidant SOD and GSHPx activities and haematological indices, including hemoglobin levels, red blood cells number, hematocrit, mean corpuscular volume, mean corpuscular haemoglobin, and mean corpuscular hemoglobin concentration were detected between pre- and post-treatment with antimony. Results indicated that the presence or absence of previous treatment with antimony had no statistically indentifiable effect on the antioxidant enzyme activity and haematological indices.