The present study aimed to evaluate the immunodulatory effects of heat-killed Lactobacillus plantarum L-137 (HK-L137) on IPEC-J2, and PBMC-derived cells and MARC145. Overall, HK-L137 did not affect cell viability, while it modulated gene expression in both cell types. Notably, HK-L137 drove PBMC-derived macrophages towards a pro-inflammatory functional phenotype, potentially useful in immune defence against pathogenic viruses and bacteria.
Effetti immunomodulanti di Lactobacillus plantarum L-137 inattivato termicamente: indagini in vitro
G. Marruchella;
2025-01-01
Abstract
The present study aimed to evaluate the immunodulatory effects of heat-killed Lactobacillus plantarum L-137 (HK-L137) on IPEC-J2, and PBMC-derived cells and MARC145. Overall, HK-L137 did not affect cell viability, while it modulated gene expression in both cell types. Notably, HK-L137 drove PBMC-derived macrophages towards a pro-inflammatory functional phenotype, potentially useful in immune defence against pathogenic viruses and bacteria.File in questo prodotto:
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