The underlying molecular mechanisms of OCD remain poorly understood. Emerging evidence suggests that microbiota composition, epigenetic regulation, and their effects on the dysregulation of endogenous signaling systems play crucial roles in the development and progression of this disorder. The overarching aim of this PhD research is thus to investigate the transcriptional regulation of genes belonging to selected endogenous systems in OCD and the possible role on these effects of microbiota dysregulation and of epigenetic mechanisms.
MICROBIOTA-HOST EPIGENETIC AXIS IN OBSESSIVE COMPULSIVE DISORDER / Girella, Antonio. - (2025 Feb).
MICROBIOTA-HOST EPIGENETIC AXIS IN OBSESSIVE COMPULSIVE DISORDER
ANTONIO GIRELLA
2025-02-01
Abstract
The underlying molecular mechanisms of OCD remain poorly understood. Emerging evidence suggests that microbiota composition, epigenetic regulation, and their effects on the dysregulation of endogenous signaling systems play crucial roles in the development and progression of this disorder. The overarching aim of this PhD research is thus to investigate the transcriptional regulation of genes belonging to selected endogenous systems in OCD and the possible role on these effects of microbiota dysregulation and of epigenetic mechanisms.File in questo prodotto:
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