The Authors in this investigation report unprecedented evidence that boar sperm cells have the machinery to bind and degrade anandamide.They also show that the non- hydrolyzable AEA analogue, methanandamide (MetAEA), reduces sperm capacitation and zona pellucida-induced acrosome reaction by binding to type-1 cannabinoid receptors (CB1R).Furthermore, activation of vanilloid receptors (TRPV1) blocks spontaneous acrosome reaction of sperm cells and inhibition of AEA transporter (AMT) prevents this effect.They show that sperm cells have a complete and efficient endocannabinoid system and that activation of receptors controls at different time-point sperm functions.[...]
Ruolo del sistema endocannabinoide sulla funzione dello spermatozoo di verro
BERNABO', NICOLA;LUCIDI, Pia;DI GIACINTO, Oriana;BARBONI, Barbara
2005-01-01
Abstract
The Authors in this investigation report unprecedented evidence that boar sperm cells have the machinery to bind and degrade anandamide.They also show that the non- hydrolyzable AEA analogue, methanandamide (MetAEA), reduces sperm capacitation and zona pellucida-induced acrosome reaction by binding to type-1 cannabinoid receptors (CB1R).Furthermore, activation of vanilloid receptors (TRPV1) blocks spontaneous acrosome reaction of sperm cells and inhibition of AEA transporter (AMT) prevents this effect.They show that sperm cells have a complete and efficient endocannabinoid system and that activation of receptors controls at different time-point sperm functions.[...]I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
