The Authors in this investigation report unprecedented evidence that boar sperm cells have the machinery to bind and degrade anandamide.They also show that the non- hydrolyzable AEA analogue, methanandamide (MetAEA), reduces sperm capacitation and zona pellucida-induced acrosome reaction by binding to type-1 cannabinoid receptors (CB1R).Furthermore, activation of vanilloid receptors (TRPV1) blocks spontaneous acrosome reaction of sperm cells and inhibition of AEA transporter (AMT) prevents this effect.They show that sperm cells have a complete and efficient endocannabinoid system and that activation of receptors controls at different time-point sperm functions.[...]

Ruolo del sistema endocannabinoide sulla funzione dello spermatozoo di verro

BERNABO', NICOLA;LUCIDI, Pia;DI GIACINTO, Oriana;BARBONI, Barbara
2005-01-01

Abstract

The Authors in this investigation report unprecedented evidence that boar sperm cells have the machinery to bind and degrade anandamide.They also show that the non- hydrolyzable AEA analogue, methanandamide (MetAEA), reduces sperm capacitation and zona pellucida-induced acrosome reaction by binding to type-1 cannabinoid receptors (CB1R).Furthermore, activation of vanilloid receptors (TRPV1) blocks spontaneous acrosome reaction of sperm cells and inhibition of AEA transporter (AMT) prevents this effect.They show that sperm cells have a complete and efficient endocannabinoid system and that activation of receptors controls at different time-point sperm functions.[...]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11575/15264
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