Amniotic fluid stem cells increase the osteoinductive property of Regenoss® scaffold in a preclinical setting of maxillary sinus lifting

The osteo-inductive property of the bone substitute RegenOss (Finceramica®) were evaluated in absence (CTR) or presence of ovine amniotic fluid stem cells (AFC) 180 days after a maxillary sinus lifting surgical approach experimental performed in a translational animal model (sheep). Both sinus explants revealed new bone deposition even if AFC induced active osteogenic fronts, a greater bone thickness and a lower cell proliferation. Moreover, some of AFC survived in the host tissue resulted integrated within the new trabecular bone. The results indicated that RegeneOss® can be successfully used in maxillo-facial surgery and that its osteo-inductive properties is potentiated by AFC that may contribute directly to the process of bone generation or, indirectly, through the recruitment of osteo-progenitor cells of the host tissue. [...]