Tissue engineering has offered novel strategies to be applied in the biomedical field since it aims to combine its main elements (cells, biomaterials, and growth factors) to generate tissue-like structures. Amniotic epithelial stem cells (AECs), due to their ability to differentiate into tenogenic lineage, have recently retained great attention in the field of regenerative medicine [1-2]. Developing tendon bio-mimetic scaffolds with good mechanical and structure properties similar to those of the native tissue may increase AECs’ potential in accelerating tendon regeneration. In this context, highly aligned electrospun PLGA scaffolds with different diameter size were fabricated to test and compare their mechanical properties as well as their teno-inductive potential on AECs.
|Titolo:||Varying Fiber Diameter Size in Tendon Biomimetic PLGA Electrospun Scaffolds Regulates Amniotic Epithelial Stem Cells Genotype and Phenotype towards the Tenogenic Lineage.|
|Data di pubblicazione:||2019|
|Appare nelle tipologie:||4.3 Poster|