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SIRT1-DEPENDENT CYTOPROTECTIVE EFFECTS OF RESVERATROL IN HIGH GLUCOSE-CHALLENGED HUMAN ENDOTHELIAL CELLS INVOLVES ANTIGLYCATIVE AND ANTIOXIDANT RESPONSES
Overproduction of methylglyoxal (MG) and reactive oxygen species (ROS) occurs in hyperglycemia-induced endothelial dysfunction associated with diabetes. Resveratrol (RSV) has been proposed as an effective treatment for diabetic complications, that is likely associated with activation of SIRT1, a NAD+ ...
Effect of graphene oxide in the in vitro capacitation of mammalian spermatozoa
Infertility currently affects around 9% of couples worldwide and in 30% of the cases, the male factor plays a role. It is clear that lifestyle and diet affect male fertility and sperm function and can affect the outcome of fertility treatments. One of the key aspects ...
The emerging role of probiotics in neurodegenerative diseases: new hope for Parkinson's disease?
Neurodegenerative disease etiology is still unclear, but different contributing factors, such as lifestyle and genetic factors are involved. Altered components of the gut could play a key role in the gut-brain axis, which is a bidirectional system between the central nervous system and&...
Repurposing a psychoactive drug for children with cancer: p27 Kip1-dependent inhibition of metastatic neuroblastomas by Prozac
The MYC family of transcription factors is a major driver of human cancer and potential therapeutic target. However, no clinically viable drugs have been yet developed that are able to directly tackle MYC oncoproteins. In our laboratory, we are exploring alternative approaches aiming&#x...
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